If you use TeamViewer for personal use only, here’s how to fix the TeamViewer trial expired problem. Make sure that you and the users you connect are using the free version of TeamViewer. If one user uses a free one and the second uses a commercial one, then the commercial version will consider the use of TeamViewer for commercial purposes. If the commercial version of TeamViewer is installed, you need to remove it, clear the registry and folders from the remaining entries and files. Then install the free version of TeamViewer.Go to Add or remove programs, find TeamViewer in the list, and select Uninstall.After removing the program, press Win R > %Appdata% > OK.Then delete the directory C:\Program Files\TeamViewer.In a safe way remove the TeamViewer folder %USERPROFILE%\AppData\Local.Germline or somatic GPR101 duplication leads to X-linked acrogigantism: a clinico-pathological and genetic studyĪcta Neuropathologica Communications volume 4, Article number: 56 ( 2016) Non-syndromic pituitary gigantism can result from AIP mutations or the recently identified Xq26.3 microduplication causing X-linked acrogigantism (XLAG). Within Xq26.3, GPR101 is believed to be the causative gene, and the c.924G > C (p.E308D) variant in this orphan G protein-coupled receptor has been suggested to play a role in the pathogenesis of acromegaly. We studied 153 patients (58 females and 95 males) with pituitary gigantism. AIP mutation-negative cases were screened for GPR101 duplication through copy number variation droplet digital PCR and high-density aCGH. The genetic, clinical and histopathological features of XLAG patients were studied in detail. 395 peripheral blood and 193 pituitary tumor DNA samples from acromegaly patients were tested for GPR101 variants. We identified 12 patients (10 females and 2 males 7.8 %) with XLAG.
In one subject, the duplicated region only contained GPR101, but not the other three genes found to be duplicated in the previously reported patients, defining a new smallest region of overlap of duplications. While females presented with germline mutations, the two male patients harbored the mutation in a mosaic state.
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